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"DJ Cameo is an English disc jockey and former host of "Pirate Sessions", a now-defunct Sunday afternoon grime show on the digital UK radio station BBC 1Xtra. He later hosted the Tuesday night UKG show, but on 4 November 2015 it was announced that he would be replaced by a new DJ called Jamz Supernova who would be playing R&B.; The music Cameo produces varies from 2-step vocals, to 4x4, to grime, and sublow. In 2004, Cameo was voted winner of the "Best Newcomer" Award for the garage scene's 2004 Peoples Choice Awards held in London. Cameo also received two back to back awards on behalf of Uptown Records, winner of best record shop. == Biography == DJ Cameo began his DJing career in 1997 playing in local bars and clubs in West London. His main influences at that time were Tuff Jam, EZ and the Dreem Teem. In March 1999, Cameo landed a set on London's 92.5 Taste FM alongside MCs Mr. Kaos and Double G, together collectively known as The Specialist Crew and later Special Edition. In their weekly 4pm–6pm Sunday show, they were amongst the early pioneers of a changing scene and introduced the concept of 'radio raving' with 2 MCs effectively 'bringing a rave into your living room'. This allowed Cameo to be heard on the UK underground music scene and to gain experience in working on a radio station. With success on Taste FM, Cameo also featured on other pirate stations such as Delight FM, Ice FM and Lush FM. In 2001, he secured a job at Uptown Records, a European underground music store and has since been promoted to head buyer for the UK garage department. That same year, Cameo teamed up with Danny C and MC Viper to produce "Addicted". Cameo then got involved with producer J-Sweet to produce the underground track "Hi Grade" featuring Mr. Kaos and Double G that was then signed to the MOBO 2002 compilation, and more recently the 2003 garage anthem "Original Bad Girl Style" featuring Gemma Fox for Ministry of Sound's Street Beats compilation. In October 2005, Cameo started his own label, On A Level, and Kamikaze Recordings working with artists such as Jon E Cash, DaVinChe, Terror Danger, P-Jam, Dexplicit, Vital, Delinquent, TnT, J-Sweet, IMP, Jiggalo, Black Jack and Scandalous. Also in 2005, the Garage Anthems CD compilation, mixed by Cameo was released on Virgin Records. Cameo went on to become head A&R; of Def Jam mobile, a ringtone company offering UK and US tracks for download. That same year, Cameo promoted his Hot Off The Block Grime Allstars concert tour alongside Rebecka Prochnik. It showcased established and new UKG talent in a live concert format enabling fans around the world to truly experience the UKG phenomena on their doorstep. A world tour was set up with dates in New York, Germany, Spain, Sweden and Paris. The UK was also covered with dates at Glastonbury Festival, V Festival, Cargo and various universities. The tour included acts such as Crazy Titch & J2K, Lethal B, Roll Deep, JME, Skepta, Bruza, No Lay, L Man, Purple and Tinchy Stryder, to name a few. It aimed to take the UKG scene to another level providing artists and producers with unlimited global exposure. In early 2006, on behalf of 1xtra and BBC Radio 3, Cameo hosted Urban Classic, a music event which brought urban street stars such as Bruza Purple Pace Tor, Faith Sfx and Davinche together with the BBC Symphony Orchestra for a performance at the Hackney Empire. Cameo also appeared on the TV drama series Dubplate Drama. ==Discography== *Garage Anthems 2005 *The Sound of the Pirates *DJ Cameo Presents Bassline ==References *DJ Cameo playing on Taste FM on YouTube *Taste FM 92.5 on YouTube *Interview With Underground Kulture Category:Year of birth missing (living people) Category:Living people Category:Black British radio presenters Category:Grime music artists Category:UK garage musicians Category:BBC Radio 1Xtra presenters Category:English people of Saint Lucian descent "
"Treasure Coast Square is a shopping mall in Martin County, Florida, United States. It comprises 115 stores, including anchor stores Dillard's, JCPenney, and Macy's, as well as a food court and Regal 16-screen movie theater. The mall is managed by Simon Property Group, and opened in 1987. ==History== The mall opened in 1987 with original anchor tenants J. C. Penney, Jordan Marsh, and Lord & Taylor. The mall's opening caused the decline of the existing Martin Square Mall in nearby Martin, from which J. C. Penney relocated, and Boca Mall (now known as Mizner Park) in Boca Raton. At the time of opening, the latter two stores included the only escalators in Martin County. A 1989 expansion brought Sears, while a second expansion in 1993 added a Dillard's department store. When Lord & Taylor closed its location at the mall in 1990, its space became Mervyns.http://articles.sun- sentinel.com/1990-11-20/business/9002260549_1_lord-taylor-taylor-sites-five- stores The Mervyns store closed in 1997 and, although Simon Property Group was initially in talks to convert the space to Bed Bath & Beyond, the space instead became a Borders Books & Music. Also, the Jordan Marsh converted to Burdines and then to Macy's. After Borders went out of business in 2011, the space became an hhgregg electronics store which closed in 2017.https://www.tcpalm.com/story/money/business/bargainista/2017/03/08/more- store-closings/98849866/ The opening of the mall attracted nearly 800,000 square feet of new retail development in its area in the first ten years of opening. On November 8, 2018, it was announced that Sears will be closing this location in early 2019 as part of a plan to close 40 stores.https://www.cnbc.com/2018/11/08/sears-to-shut-40-more-stores-early- next-year.html ==References External links == * Treasure Coast Square Mall home page Category:Simon Property Group Category:Shopping malls in Florida Category:Buildings and structures in Martin County, Florida Category:Tourist attractions in Martin County, Florida Category:Shopping malls established in 1987 "
"Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor.Allan RD, Johnston GAR, Twitchin B. Effects of Gabaculine on uptake, binding and metabolism of GABA. Neuroscience Letters. 1977;4:51-54. Gabaculine is also known as 3-amino-2,3-dihydrobenzoic acid hydrochloride and 5-amino cyclohexa-1,3 dienyl carboxylic acid. Gabaculine increased GABA levels in the brain and had an effect on convulsivity in mice. == Mechanism of action == Gabaculine includes a comparable structure to GABA and a dihydrobenzene ring. This comparable GABA structure is used in order to be able to take the place of GABA during the first steps of transamination, including transaldimination and 1,3-prototrophic shift to the pyridoxamine imine. Following this, a proton from the dihydrobenzene ring is abstracted by an enzymatic base, thus causing the ring to become aromatic. The aromatic stabilization energy of the aromatic ring is what causes this reaction to be irreversible, thus causing the complex not to react further. ==Preclinical studies== Animal studies to determine the effect of gabaculine on GABA levels in the brain were heavily conducted around the 1970s. These in vivo studies involved mostly the use of mice that underwent intravenous administration of this drug. Each of these studies concluded that gabaculine has a great potential to increase the GABA levels in the brain of these mice in a time dependent manner. Along with determining the effect of GABA levels, in vivo studies were conducted to investigate the ability of gabaculine to inhibit convulsions in mice. Results indicated that gabaculine provided a clear anticonvulsant effect against seizures induced by high doses of chemoconvulsants or electroshock. The toxicity of this compound was also investigated using animal mouse models. This study showed that at anticonvulsant doses, gabaculine is extremely potent and toxic when compared to other GABA transaminase inhibitors, with an ED50 of 35 mg/kg and of 86 mg/kg. Because of this potential lethal effect, gabaculine was proved to be too toxic for use as a drug however, it can still be used as a compound to alter GABA levels in studies of experimental epilepsy. ==Regulation== Gabaculine has not been approved by the FDA as a pharmaceutical entity; however, it can be used as a chemical compound for research purposes only. This compound is not considered a hazardous substance according to OSHA 29 CFR 1910.1200. ==References== Category:Neurotoxins Category:GABA transaminase inhibitors Category:GABA reuptake inhibitors Category:Amines Category:Carboxylic acids Category:GABA analogues "